DRUG DEMAND REDUCTION: PREVENTION
 
Prevention Philosophy
One of the premises of drug prevention policy and education is that information should be presented in a realistic and non-moralistic manner, emphasising a personal responsibility for one's health.
Information and education activities for young people, have been around for years. Initially, they consisted primarily of a transfer of knowledge, combined with warnings and cautions. But research showed that this had no effect or even a negative effect. What is more, young people have a natural need to experiment and much experimental use does stop eventually. These days, a key premise is that it is better to steer the inevitable experiments in the right direction by means of credible information and education. Which is why these have to be backed up with facts and any exaggeration of the risks has to be avoided. Alcohol and drug use have been stripped of their taboo image and of the sensational and emotional tone of voice that did in fact act as an attraction. What has to be prevented, however, are any permanent harmful effects due to experimenting, whether or not this is the result of pressure from peers or others. Research showed that education increases knowledge and changes attitudes but has insufficient effect on actual behaviour. Broader-based prevention programmes are therefore considered more important in the Netherlands. In addition to offering knowledge, therefore also promote behavioural skills, such as increasing the resistance of young people, teaching them to deal with peer pressure and improving their decisiveness.
 
The difference between primary and secondary prevention is getting smaller and smaller. For both, risk reduction is the main focus. The message in prevention is: use sensibly.
Structure of Prevention Activities
The Dutch government creates the conditions for the development, implementation and evaluation of prevention, information and education. The implementation occurs in a variety of institutions such as schools, local and regional addict care organisations, The Municipal Health Services, the police and several national bodies.
The National Prevention Support Centre
The National Support Centre on Drug Prevention (Landelijke Steunfunctie Preventie - verslaving en middelengebruik), which is subsidised by the Ministry of VWS, co-ordinates and supervises the prevention efforts. Programmes of work are co-ordinated in consultation with the heads of prevention departments and priorities are specified for development, standardisation and research. Next to this task the LSP offers a help desk for the institutions offering assistance with information provision, the promotion of expertise, and innovation. The LSP ensures that there is a coherent relationship with prevention activities in the field of mental care and therefore it is structurally linked with the National Prevention Support centre for the Mental Health Care sector. The programmes of these bodies are co-ordinated and priorities set during primary consultations and half yearly meetings to discuss their schedule of work. These priorities include the improvement of quality , collaboration in connection with the internet and the consolidation of secondary prevention. The LSP also works together with the prevention development centre within the context of the programme ‘Achieving Results’ . Amongst other things this centre is involved in developing an Electronic Prevention Project File,(EPPD). This tool will make a major contribution to daily operations and will also promote the standardisation of preventive intervention and the potential for evaluation.
 
Primary prevention, Examples of National Primary Prevention Activities
National Campaign: Drugs Do Not Be Fooled !
The Trimbos Institute in collaboration with over  60 regional addict care institutions and Municipal medical and Health Services organised a campaign in 2000 and 2001 entitled: ‘Drugs do not be fooled’( Drugs, laat je niks wijsmaken !). Its aim was to encourage and to improve the communication about drugs between young people and their parents, and to influence the information seeking behaviour of young people.
 
The Drugs Information Telephone Line
In 1996, the Drugs Information Telephone Line was launched to improve the provision of information and education activities relating to drugs. This project is part of the Trimbos Institute and is aimed at meeting the demand from the general public for factual and reliable information. Intermediary groups, the public and the media can use it as a source of information. National and local institutes and government authorities are supported with services and products, such as improving the quality of products, distributing information materials and conducting information and education campaigns. There is a database with existing information and education materials, and information is provided via the Internet. The telephone line is open 24 hours a day. They can choose to be sent printed information about drugs or to have personal talk with a member of the Drug Information Line’s staff. The callers can also be referred to a regional institute for further assistance.
 
In 2001 34% (11.017) opted for a personal call compared to 28 % (9.816) in 2000. The drugs about which the largest numbers of questions are asked were cannabis,; these were followed by XTC and then cocaine. Most of the questions were about the risks of use. The peak number of calls was connected with the afore mentioned campaign "drugs, do not be fooled’. The number of the Drug Information line appeared prominently in all the publicity of the campaign.
 
Healthy Schools and Stimulants
The project 'Healthy schools and substances' (gezonde school en genotmiddelen), specifically aimed at secondary school pupils, was launched in 1991. The project is a co-operative effort on the part of the Trimbos Institute, the out-patient facilities for addiction care and local public health services, together with local authorities. The project provides information on tobacco, alcohol, cannabis and gambling, aimed specifically at the ages at which students generally have their first contacts with the substance in question or with gambling. For cannabis this is usually around 15 years old. Besides providing information, the project is also aimed at establishing regulations (no substance use in schools), detection and guidance. By mid 1996, 30% of schools were implementing this project on a structural basis. In 2001 the number of participating secondary schools had increased to 75%.
The ResCon research centre evaluated the project over the period 1995-1998 . It reveals that its combination of an informative approach with an individual-oriented approach is producing an effect. Students in schools where this project was carried out show greater awareness in their dealings with tobacco, alcohol and cannabis, and are better informed about these substances. Different groups of school students also showed a lower frequency of use, and their intention to use drugs appeared to be lower than in schools where the project was not carried out.. In addition students attending schools participating in the project know better than their counterparts at other schools whom they can approach about problems connected with drug use.
The project has recently been updated and its scope has been expanded. Various new interventions have also been added. One example of these is ’No deal!’, which provides schools and support institutions withguidelines for collaborating with the police to combat drug dealing in and around
schools. Another project is ’Active Pupils’ [Actieve leerlingen], which fits in with the trend towards the use of pupil-mentor relationships in the education sector.
For information on primary prevention activities and XTC see: prevention policy on XTC
 
Secondary Prevention: Harm Reduction

Harm reduction can be defined as follows:

If a drug user (man or woman) is not capable or willing to give op his drug use, he should be assisted in reducing the harm caused to himself and others.

In this definition, the type of drug is unspecified, inferring that any drug, be it legal or illegal, can either be used in a ‘hard’ or ‘soft’ manner. It speaks about ‘user’ rather than ‘addict’ or ‘abuser’, implying that irregular use of drugs could also cause harm (for example overdose taken by inexperienced user). The definition refrains from moralism, and assumes that, if someone continues to use drugs, this should be accepted as a fact. However, this should not be interpreted as defeatism, since the definition clearly speaks about ‘should be assisted in reducing the harm.....’ , which indicates that society and helping agencies have an obligation to do something. The definition sees a modest role for the helping agencies (‘assisted’) and trusts in self-regulation and self-determination of drug users. Furthermore, it talks about ‘reducing’ and not about ‘elimination’ of drug related harm. Finally, ‘harm’ is defined as harm drug users cause to themselves as well as to others.
 
Harm Reduction in Practice
Assistance to drug addicts, who are either unwilling or unable to give up drug use, is aimed at the reduction of health risks and the improvement of the addict's quality of life. In order to reach as many addicts as possible harm reduction activities are usually incorporated in low-threshold programs. These activities can be: the provision of methadone, sterile needles, food, medical care user rooms, accommodation etc.
 
Secondary Prevention Activities
Methadone Programmes
One of the key elements of assistance to drug addicts in the Netherlands is the supply of methadone to replace heroin. From the  LADIS report 2000 it appears that a total of 13.500 hard drug users participated in a methadone program of one of the participating institutions.
Methadone is a synthetic opiate, and also addictive, but it has some advantages over heroin. Dosages, in tablet or liquid form, can be measured precisely, and it can be taken orally. It is effective for 12 to 24 hours, while heroin only works for 3 to 6 hours. Methadone is usually supplied on a maintenance basis (continuous supply of the same dose) or on a reduction basis (gradually downgrading within 1 to 6 months). In reduction programs methadone is supplied to reduce opiate withdrawal symptoms in order to achieve complete abstinence. However, cutting down methadone seems difficult to achieve. Therefore, over three-fourths of the methadone programs is based on maintenance. The primary objectives of methadone maintenance programs are: the prevention of progressive health deterioration, and to keep in touch with drug users. This makes medical supervision possible. This is important regarding the prevention of a further spread of infectious diseases such as AIDS, TBC, hepatitis B and C. Supplying methadone may also enable heroin addicts to live a structured life, that - in turn - may increase their chances of successful social integration and, in the long run, a drug-free existence.
The main prerequisite for placement in the methadone programs is heroin dependence. A medical examination takes place upon admittance, followed by regular check-ups. In most methadone maintenance programs, simultaneous use of drugs, alcohol or psychoactive medicine is permitted, if used at moderation. Methadone is mainly dispensed by CAD's. In some cases other institutions operate methadone programs (the Municipal Health Service in Amsterdam, Triton in Den Helder, Symbion in Rotterdam). Methadone is being supplied in departments of the institutes, or in buses that follow certain routes along different locations in some of the major cities. In some cities general practitioners and other physicians prescribe methadone, particularly to older, relatively well functioning heroin addicts. In some cases, it is possible to receive methadone in some of the detention houses, prisons or police offices.
 
Evaluation of methadone programmes
Evaluation studies of methadone programs revealed positive results regarding the health of drug addicts. Over a third of the clients are able to control their drug addiction and hardly use other drugs. About a fourth are well integrated into society in terms of social contacts, work, education, housing and keeping their appointments. However, the majority are marginally integrated into society and continue to use other drugs such as heroin and cocaine. For one fourth of the opiate addicts methadone has either slight or no positive effects. These extremely problematic users are characterised by uncontrolled drug use, poor health and criminal behaviour.
 
Methadone in High Doses
Comparatively Low doses of methadone (averaging 40 mg/day) have traditionally been dispensed in the Netherlands, even in maintenance programs. Promising results have been achieved in the United States with the dispensation of high doses (>60 mg/day) for maintenance purposes. Additional use of heroin decreases, the psychiatric and social situation of the addict improves and there is a decline in crime. An experiment has been started in the Netherlands to find out if the Dutch situation can be improved in a similar way.
The Dutch study into the effects of large doses of methadone has demonstrated that addicts who received a large dose of methadone (more than 85 mg) were using less heroin two years later and were also in better health and felt better mentally than addicts who received a small dose. The treatment does not produce any clear social benefits; it has a favourable effect on the addict’s social network, but not on criminal behaviour, housing or participation in work. The treatment with large doses of methadone fits in with the regular treatment of heroin addicts. Although large doses of methadone clearly produce better results, the treatment is not completely risk-free. Near-accidents, such as near overdoses, were slightly more common in the experimental group. Because of
this, the researchers’ made recommendations concerning protocol development and a
monitoring system to prevent (near) accidents. This year the addict care sector will work within the framework of the ’Achieving Results’ [Resultaten Scoren] programme to review the methadone programmes and develop protocols in this area. The recommendations of the study on large
doses of methadone will be incorporated into these protocols.
 
Needle Exchange
Sharing needles/syringes increases the risk of infection with HIV/AIDS and hepatitis B and C. Therefore, several syringe exchange programs have been developed in the eighties that enable injecting drug users to obtain free sterile syringes after returning used ones. When the first needle exchange was started in Amsterdam, in the summer of 1984 (initiated by the Junky Union), its goal was to prevent Hepatitis B infection. Soon after that, the necessity of Aids prevention arose. In 1985 other institutions took over the initiative. In other cities in the Netherlands, needle exchange programmes were also started. Soon other countries in Europe and Australia followed.
 
Syringe exchange facilities are located at Municipal Health Services, addiction care services, private locations, change machines, mobile exchange centres or at pharmacies. Sometimes drug users can also buy injecting equipment such as alcohol swabs and ascorbic acid. In 60 different cities in the Netherlands, 130 syringe exchange programs are being run. In most of the cases these services are part of a methadone program.
Evaluation of the Amsterdam needle and syringe exchange program showed that no increase in drug use could be validated, participants of the exchange schemes were less involved in needle sharing, the supply of large quantities of needles to hard drug users did not lead to an increase in needle stick accidents by the general public, and, finally, the HIV prevalence among drug injectors remained stable since 1986, while the incidence of acute hepatitis B had gone down. 
 
Prevention of Infectious Diseases
In the context of prevention of infectious diseases, information is provided to drug users. Regarding HIV prevention, several projects have been developed based on the premise that information given to drug users ('safer sex and safer use') is most effective when provided by drug users themselves. This type of peer support is particularly effective for drug users who are hard to reach by the regular addiction treatment and assistance system. Moreover, measures such as the methadone and syringe exchange programs have a preventive value also with respect to drug-related diseases and the harmful effects of drug use on society.
 
Hepatitis B Vaccination Program
Research has been going on since October 1998 into the feasibility and penetration of a hepatitis B vaccination program, aimed at different risk groups (such as people who use hard drugs). So far it has become clear that the willingness of the group of hard drug users to participate in the program is high. More than 200 users have been vaccinated so far.
 
HIV/AIDS Prevention
In the Netherlands, only 13% of the hard drug users inject their drugs. A large majority of 75% smoke the drug. The number of intravenous drug users remains low in comparison with surrounding countries. The percentage of intravenous drug users as a percentage of HIV is 10, 5 %
Aids prevention among hard drug users consists of very many different activities. For example Information is given to drug users about safer sex and safer drug use, condoms are made available, clean needles are provided through needle exchange schemes.
User Rooms
Some cities have opened special centres to deal with the problems that homeless hard drug users cause in the streets. In these centres, hard drug addicts can take their daily dosages and receive assistance from care workers. The centres are not allowed to sell or supply drugs. Local residents support this initiative, and take part in consultations on the running of the centres.
The Public Prosecutions Service has imposed a number of conditions for the introduction of user rooms. They must be part of the municipality's integrated policy on drugs, and public health and safety must be safeguarded.
 
Evaluation User Rooms
User rooms were studied by the Trimbos Institute in 2002. They reviewed various studies and concluded that all studies indicate that user rooms have a positive effect on the state of health of those using them, that they lead to a reduction in nuisance and that they increase the reach of the addict care services. However, in some cases drug dealing in close vicinity of the user rooms was observed. This is why it would be important not to concentrate facilities in one area.
 
Heroin Treatment
Heroin experiment
To improve the treatment of heroin addicts political approval of the heroin experiment was obtained in 1999.
 
The objective of the heroin experiment was that participants improve their mental and physical health and ameliorate their social functioning. In case the social functioning improves, criminal behaviour will reduce, as well as public nuisance caused by drug addicts
It was clear from the experiences in Amsterdam and Rotterdam, that the first two treatment units were not experiencing any significant problems in the areas of safety, manageability and public order. As of August 1999, 100 participants have been involved in the study in Amsterdam. There are 92 participants in Rotterdam. The experiment was expanded to various other cities in the beginning of 2000. In Amsterdam, a second treatment unit was opened. In February 2002, the results were presented to the Minister of Health (Minister Borst). The main conclusions were:
Conclusion 1.
The study was conducted and analyzed successfully.
 
Conclusion 2.
Supervised co-prescription of heroin to chronic, treatment-resistant heroin dependent and methadone treated patients is more effective than the continuation of methadone alone.
 
Conclusion 3.
Supervised co-prescription of heroin to chronic, treatment-resistant heroin dependent and methadone treated patients yields clinically relevant health benefits.
 
Conclusion 4.
The beneficial effects of supervised co-prescription of heroin are linked to the continuation of treatment.
 
Conclusion 5.
Supervised medical co-prescription of heroin is practicable with no excess of serious medical adverse events and with a limited number of controllable public order problems.
 
Conclusion 6.
The costs of the medical prescription of heroin are dependent on the type of treatment implementation.
 
For more information: www.ccbh.nl

 

Deterioration of condition of patients after the heroin experiment
80% of patients were significantly deteriorated 2 months after ending the heroine programme and the gains in terms of health improvement perished. This does not mean that this treatment has to be carried out for life. The experiment foresees in a treatment period of 12 months. This is due to the research protocol. In the future, a decision will be made based on a individual assessment of the patient to see for how long prescription of heroin is desirable and justified. Based on –yet to develop- criteria, treatment with heroin will be evaluated individually. This means that it will not be a treatment with an open end, but limited between various evaluations. Switzerland has this form of treatment since 1994. There, the average duration of treatment is 3,3 years. Yearly, 20-30% moves from the heroin programme to a detoxification programme and about 33% moves on to a methadone programme
 
Present policy regarding the prescription of heroin
In 2002, the Minister of Health (VWS) has installed a committee to advice him regarding the implementation of treatment with heroin. This committee advised to set up 15 units. The new government has agreed that after evaluation of the present projects in Amsterdam, Rotterdam, the Hague, Utrecht, Heerlen and Groningen, a decision will be made. The results of the evaluation are expected in the beginning of 2004.
Until a decision has been made, the present situation continues, which means that the prescription of heroin is part of a scientific experiment. For this experiment, 5 million Euros is available yearly for a total of 300 places.
 
EDOCRA/detoxification under anaesthetic
Another study was undertaken to improve the treatment of heroin addicts: detoxification with the aid
of naltrexon,
 
In the EDOCRA study high-speed detoxification was carried out with the aid of the opiate antagonist naltrexon. A general anaesthetic was also administered to the control group in a general hospital. After this, both groups received 10 months of outpatient treatment. The study will continue, but the short-term results indicate that detoxification with naltrexon under anaesthetic is no more effective than detoxification with naltrexon alone; however, it is more expensive and slightly less safe. Next year it will become clear whether this effect is also evident in the long term.
More information: http://www.novadic.nl/edocra.htm